In this research, information about Science, Technology, Engineering and Mathematics (STEM) and Distance education was given to prospective science teachers and the integration of STEM into courses was emphasized. On the other hand, an experimental study was conducted to support the research on STEM Education and distance education. The study group of this research consisted of 328 science teacher candidates studying in the 4th grade of university. Some of these students were randomly selected as the experimental group and the others as the control group. In the study carried out in the science laboratory course, while the course was taught according to STEMEducation and Distance Education in the experimental group; In the control group, the lessons continued as normal. The application in question was carried out based on a quasiexperimental study. The study was implemented during the 2020-2021 fall semester. Before the application, the learning level test, which was valid and reliable, was applied regarding the subjects. As a result of the application, a significant difference was found between the students in the experimental group and the students in the control group in favor of the experimental group in which STEMEducation and Distance Education were applied. In line with these results, STEM Education and Distance Education were found to be effective in improving the success of university teacher candidates, and it was added to the research results. © 2021. International Journal of Emerging Technologies in Learning. All Rights Reserved.