High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles

The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-molecular-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH4. The derivative of moderate molecular weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin. © 2021

Authors
Kritchenkov A.S. 1, 2 , Kurasova M.N. 1 , Godzishevskaya A.A. 1 , Mitrofanova E.S. 1 , Egorov A.R. 1 , Yagafarov N.Z. 1, 3 , Ballesteros Meza M.J. , Tskhovrebov A.G. 1 , Artemjev A.A. 1 , Andrusenko E.V.4 , Khrustalev V.N. 1, 5
Journal
Mendeleev Communications
Publisher
Royal Society of Chemistry
Number of issue
4
Language
English
Pages
504-506
Status
Published
Link
External link
DOI
10.1016/j.mencom.2021.07.022
Volume
31
Year
2021
Organizations
  • 1 Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation
  • 2 Institute of Technical Acoustics, National Academy of Sciences of Belarus, 210009 Vitebsk, Belarus
  • 3 N. I. Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation
  • 4 Department of Chemistry, Institute of Chemistry and Chemical and Pharmaceutical Technology, Altay State University, Barnaul, 656049, Russian Federation
  • 5 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Keywords
antibacterial activity; chitosan; low toxicity; nanoparticles; pyridoxal
Date of creation
16.12.2021
Date of change
16.12.2021
Short link
https://repository.rudn.ru/en/records/article/record/76741/
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