HUMAN SPORT MEDICINE.
SOUTH URAL STATE UNIV, SCIENTIFIC RESEARCH DEPT.
Vol. 21.
2021.
P. 85-92
High antibacterial activity and low toxicity of pyridoxal derivatives of chitosan and their nanoparticles
The pyridoxal derivatives of chitosan with various degrees of substitution (DS) were synthesized from low-, moderate- and high-molecular-weight chitosans by their reaction with pyridoxal followed by treatment with NaBH4. The derivative of moderate molecular weight and high DS demonstrated a maximum antibacterial activity against S. aureus and E. coli. The nanoparticles of this derivative obtained by ionic gelation are nontoxic, and they exhibit a high in vitro antibacterial effect, which slightly exceeds that of ampicillin and gentamicin. © 2021
Authors
Kritchenkov A.S.
1,
2
,
Kurasova M.N.
1
,
Godzishevskaya A.A.
1
,
Mitrofanova E.S.
1
,
Egorov A.R.
1
,
Yagafarov N.Z.
1,
3
,
Ballesteros Meza M.J. ,
Tskhovrebov A.G.
1
,
Artemjev A.A.
1
,
Andrusenko E.V.4
,
Khrustalev V.N.
1,
5
Journal
Publisher
Royal Society of Chemistry
Number of issue
4
Language
English
Pages
504-506
Status
Published
Link
Volume
31
Year
2021
Organizations
- 1 Peoples Friendship University of Russia (RUDN University), 117198 Moscow, Russian Federation
- 2 Institute of Technical Acoustics, National Academy of Sciences of Belarus, 210009 Vitebsk, Belarus
- 3 N. I. Pirogov Russian National Research Medical University, Moscow, 117997, Russian Federation
- 4 Department of Chemistry, Institute of Chemistry and Chemical and Pharmaceutical Technology, Altay State University, Barnaul, 656049, Russian Federation
- 5 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Keywords
antibacterial activity; chitosan; low toxicity; nanoparticles; pyridoxal
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Doklady Biochemistry and Biophysics.
Vol. 499.
2021.
P. 247-250