International Journal on Minority and Group Rights. Vol. 10. 2003. P.. 203-220
Synthesis of novel cytotoxic 3-azolylsteroids via Cu-catalyzed C–N coupling
A series of novel 3-azolylandrosta-3,5-dienes was prepared via Cu-catalyzed Ullmann C–N coupling between a readily available steroidal vinyliodide and a variety of NH-heterocycles. The cytotoxic activity of the target compounds was evaluated against selected cancer cell lines (MCF-7, SKOV-3, DU-145, PC-3). Compound bearing gramine fragment showed the highest antiproliferative effect with IC50 values in the range of 2.0–10.1 μm. © 2021
Authors
Parulava M.J. 1 , Kotovshchikov Y.N. 1 , Latyshev G.V. 1 , Sokolova D.V. 2, 3 , Beletskaya I.P. 1 , Lukashev N.V. 1
Journal
Publisher
Royal Society of Chemistry
Issue number
3
Language
English
Pages
359-361
State
Published
Link
Volume
31
Year
2021
Organizations
- 1 Department of Chemistry, M. V. Lomonosov Moscow State University, Moscow, 119991, Russian Federation
- 2 Peoples Friendship University of Russia (RUDN University), Moscow, 117198, Russian Federation
- 3 N. N. Blokhin National Medical Research Center of Oncology, Moscow, 115478, Russian Federation
Keywords
antiproliferative activity; copper catalysis; iodoalkenes; MTT assay; nitrogen heterocycles; steroids
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Other records
Russian Chemical Bulletin. Vol. 70. 2021. P.. 949-959