Rifaximin-alpha and other crystalline forms of rifaximin: Are there any differences?

Rifaximin is an antibiotic characterized by polymorphism. It has various crystalline forms with different pharmacological characteristics. Rifaximin acts locally in the digestive tract, therefore it is important for the absorption to be minimal and for concentration in the intestinal lumen to be high. The absorption of other crystalline forms of rifaximin in the intestine is greater than that of rifaximin-α (Alpha Normix®). Differences in pharmacokinetics of the crystalline forms of rifaximin may affect its effectiveness and safety, especially in patients with chronic diseases (immunodeficiency and leaky gut against the background of liver cirrhosis) who require long courses of therapy. Rifaximin-α (Alpha Normix®) is unique as it has eubiotic and anti-inflammatory properties in addition to local antibacterial effect. Given its diverse mechanisms of action, rifaximin-α positively modulates gut microbiota. © 2020 Media Sphera Publishing Group. All rights reserved.

Number of issue
7-8
Language
Russian
Pages
52-62
Status
Published
Volume
65
Year
2020
Organizations
  • 1 RUDN University, Moscow, Russian Federation
Keywords
Bacterial overgrowth syndrome (BOS); Bioavailability; Hepatic encephalopathy; Irritable bowel syndrome (IBS); Local antibiotic; Polymorphism; Rifaximin-α; Solubility; Symptomatic uncomplicated diverticular disease (SUDD); Traveler's diarrhea
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/72763/
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