Comparative genome analysis of global and Russian strains of community-acquired methicillin-resistant Staphylococcus aureus ST22, a ‘Gaza clone’

In this study, we identified the relationship between the genetic lineage of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) sequence type 22 (ST22) from Russia and other regions. Sixty ST22 isolates from Russia were characterised through whole-genome sequencing. To evaluate the phylogenetic relationship of Russian isolates with the global ST22 population, we analysed 1283 genomes obtained from NCBI's GenBank. The phylogenetic tree of the ST22 global population consisted of three main clusters (A, B and C). The first (cluster A) was represented by EMRSA-15 isolates, the second (cluster B) by heterogeneous isolates from different regions harbouring different sets of virulence genes, and the third (cluster C) by isolates from the Middle East previously recognised as ‘Gaza clone’ and similar isolates from Russia. Presence of the toxic shock syndrome toxin (tsst) and elastin-binding protein S (ebpS) genes as well as the hypothetical proteins NCTC13616_00051 and NCTC13616_00047 were the most useful factors in discriminating ST22 lineages. Although the CA-MRSA ‘Gaza clone’ was mainly recovered from carriers, its widespread occurrence is a cause for concern. Differentiation of the ‘Gaza clone’ from other MRSA lineages is necessary for planning infection control measures. © 2020 Elsevier Ltd

Authors
Gostev V.1, 2 , Ivanova K.1, 3 , Kruglov A.4 , Kalinogorskaya O.1 , Ryabchenko I.4 , Zyryanov S. 5, 6 , Kalisnikova E.1 , Likholetova D.1, 7 , Lobzin Y.1, 2 , Sidorenko S.1, 2
Publisher
Elsevier B.V.
Number of issue
2
Language
English
Status
Published
Number
106264
Volume
57
Year
2021
Organizations
  • 1 Pediatric Research and Clinical Center for Infectious Diseases, Saint Petersburg, Russian Federation
  • 2 North-Western State Medical University named after I.I Mechnikov, Saint Petersburg, Russian Federation
  • 3 ITMO University, Saint Petersburg, Russian Federation
  • 4 National Agency for Clinical Pharmacology and PharmacyMoscow, Russian Federation
  • 5 Peoples’ Friendship University of Russia (RUDN University)Moscow, Russian Federation
  • 6 City Hospital № 24Moscow, Russian Federation
  • 7 Saint-Petersburg State University, Saint Petersburg, Russian Federation
Keywords
CA-MRSA; Colonisation; ST22; Whole-genome sequencing; ‘Gaza clone’
Date of creation
20.04.2021
Date of change
16.08.2021
Short link
https://repository.rudn.ru/en/records/article/record/72175/
Share

Other records