Priming with a gonadotropin-releasing hormone agonist before immature oocyte retrieval may improve maturity of oocytes and outcome in in vitro maturation (IVM) cycle: a case report

Background: The concept of using a gonadotropin-releasing hormone agonist (GnRH-a) instead of human chorionic gonadotropin for triggering ovulation in patients treated with an antagonist protocol for in vitro fertilization (IVF) has become a routine clinical practice. It may promote oocyte nuclear maturation, resumption of meiosis and cumulus expansion. It seems that this attempt could be beneficial in an in vitro maturation (IVM) oocyte cycle performed for polycystic ovarian syndrome as well as for other indications such as urgent fertility preservation in patients with malignancies or unusual indications. Case presentation: We present the case of a Caucasian patient who needed fertility preservation when routine natural IVF treatment did not yield oocyte retrieval, followed by three IVM cycles, priming ovulation with a GnRH-a. In total, 12 oocytes were obtained, all matured 4.5 hours after incubation in maturation media. The fertilization rate after intracytoplasmic sperm injection was 83%. Six good-quality embryos were vitrified. Conclusions: It seems that triggering with a GnRH-a in selected cases may replace human chorionic gonadotropin in IVM of oocytes and could be highly beneficial in terms of obtaining high-grade embryos and possible pregnancy. © 2021, The Author(s).

Authors
Smirnova A. 1, 2 , Anshina M. 1, 2 , Paz E.S.3, 4 , Ellenbogen A.4
Publisher
BioMed Central Ltd
Number of issue
1
Language
English
Status
Published
Number
134
Volume
15
Year
2021
Organizations
  • 1 IVF and Genetics Center “FertiMed”, Moscow, Russian Federation
  • 2 Department of Endocrinology, Postgraduate Medical Faculty, IVF Unit, Russian University of People’s Friendship, Moscow, Russian Federation
  • 3 Hillel Yaffe Medical Center, Hadera, Israel
  • 4 Rappaport School of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Keywords
Case report; GnRH agonist priming; In vitro fertilization; In vitro maturation; IVF; Oocyte
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/71947/
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