Magnesium level correlation with clinical status and quality of life in women with hormone related conditions and pregnancy based on real world data

This study was aimed to assess the effectiveness of magnesium (Mg)-vitamin B 6 replenishment and its correlation with clinical status in pregnant women (PW), and quality of life in women with hormone-related conditions (HRCW) and hypomagnesemia (HME). Data collected in four observational studies were pooled and analysed. All women received Mg supplementation for 4 weeks. The proportion of women with normalized Mg level, and the correlation between serum Mg dynamics and number of symptoms/complaints (PW) or changes in World Health Organization quality of life questionnaire scores (WHOQOL; HRCW) were evaluated. 869 PW and 957 HRCW were included in the study. Normalization of serum Mg level to ≥ 0.66 mmol/L occurred in 92.1% of PW and 78.4% of HRCW, and to ≥ 0.8 mmol/L in 73.8% and 58.9%, respectively. Mg normalization was accompanied by a median decrease of 1 symptom and 1 complaint in PW. Serum Mg level increase by 0.1 mmol/L was associated to significant changes in the WHOQOL scores in HRCW. Treatment of HME with the Mg for approximately 4 weeks provided a high response rate of Mg serum level, was associated with an improvement in symptom severity and complaints in PW, and WHOQOL score in HRCW. A 0.8 mmol/L cut-off appeared to be more relevant in terms of patient-reported outcomes. © 2021, The Author(s).

Authors
Orlova S. 1 , Dikke G.2 , Pickering G.3, 4 , Djobava E.5 , Konchits S.6 , Starostin K.6
Publisher
Nature Publishing Group
Number of issue
1
Language
English
Status
Published
Number
5734
Volume
11
Year
2021
Organizations
  • 1 Department of Dietetics and Clinical Nutritiology of Continuing Medical Education, Medical Institute, RUDN University, Moscow, Russian Federation
  • 2 Department of Obstetrics and Gynecology with a Course of Reproductive Medicine, The Academy of Medical Education F.I. Inozemtsev, Saint-Petersburg, Russian Federation
  • 3 Department of Clinical Pharmacology Inserm CIC 1405, University Hospital, Clermont-Ferrand, France
  • 4 Inserm 1107 Fundamental and Clinical Pharmacology of Pain, Medical Faculty, Clermont-Ferrand, France
  • 5 Department of Obstetrics and Gynecology, Russian National Research Medical University, Moscow, Russian Federation
  • 6 Department of Medical Affairs, Sanofi, Business Center “Summit”, Tverskaya 22, Moscow, 125009, Russian Federation
Date of creation
20.04.2021
Date of change
20.04.2021
Short link
https://repository.rudn.ru/en/records/article/record/71948/
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