Cadmium and atherosclerosis: A review of toxicological mechanisms and a meta-analysis of epidemiologic studies

Cadmium has been proposed to be the one of the factors of atherosclerosis development, although the existing data are still controversial. The primary objective of the present study is the review and the meta-analysis of studies demonstrating the association between Cd exposure and atherosclerosis as well as review of the potential mechanisms of such association. We performed a systematic search in the PubMed-Medline database using the MeSH terms cadmium, cardiovascular disease, atherosclerosis, coronary artery disease, myocardial infarction, stroke, mortality and humans up through December 20, 2017. Elevated urinary Cd levels were associated with increased mortality for cardiovascular disease (HR = 1.34, 95% CI: 1.07–1.67) as well as elevated blood Cd levels (HR = 1.78, 95% CI: 1.24–2.56). Analysis restricted to never smokers showed similar, though more imprecise, results. Consistently, we also observed an association between Cd exposure markers (blood and urine) and coronary heart disease, stroke, and peripheral artery disease. Moreover, Cd exposure was associated with atherogenic changes in lipid profile. High Cd exposure was associated with higher TC levels (OR = 1.48, 95% CI: 1.10–2.01), higher LDL-C levels (OR = 1.31, 95% CI 0.99–1.73) and lower HDL-C levels (OR = 1.96, 95% CI: 1.09–3.55). The mechanisms of atherogenic effect of cadmium may involve oxidative stress, inflammation, endothelial dysfunction, enhanced lipid synthesis, up-regulation of adhesion molecules, prostanoid dysbalance, as well as altered glycosaminoglycan synthesis. © 2018 Elsevier Inc.

Tinkov A.A. 1, 2, 3 , Filippini T.4 , Ajsuvakova O.P.5 , Skalnaya M.G. 2 , Aaseth J.6, 7 , Bjørklund G.8 , Gatiatulina E.R.9 , Popova E.V.10 , Nemereshina O.N.9 , Huang P.-T.11 , Vinceti M.4 , Skalny A.V. 1, 2, 12, 13
Academic Press Inc.
  • 1 Yaroslavl State University, Yaroslavl, Russian Federation
  • 2 Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation
  • 3 Institute of Cellular and Intracellular Symbiosis, Russian Academy of Sciences, Orenburg, Russian Federation
  • 4 CREAGEN, Environmental, Genetic and Nutritional Epidemiology Research Center, University of Modena and Reggio Emilia, Modena, Italy
  • 5 All-Russian Research Institute of Phytopathology, Odintsovo, Moscow Region, Russian Federation
  • 6 Faculty of Public Health, Inland Norway University of Applied Sciences, Elverum, Norway
  • 7 Research Department, Innlandet Hospital Trust, Brumunddal, Norway
  • 8 Council for Nutritional and Environmental Medicine, Mo i Rana, Norway
  • 9 South-Ural State Medical University, Chelyabinsk, Russian Federation
  • 10 St. Joseph University in Tanzania, St. Joseph College of Health Sciences, Dar es Salaam, Tanzania
  • 11 Wan Fang Medical Center, Taipei, Taiwan
  • 12 Orenburg State University, Orenburg, Russian Federation
  • 13 Trace Element Institute for UNESCO, Lyon, France
Cadmium; Coronary heart disease; Lipid profile; Peripheral artery disease; Stroke
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Topouchian J., Labat C., Gautier S., Bäck M., Achimastos A., Blacher J., Cwynar M., Pall D., Fantin F., Farkas K., Garcia-Ortiz L., Hakobyan Z., Jankowski P., Jelakovic A., Kobalava Z., Konradi A., Kotovskaya Y., Kotsani M., Lazareva I., Litvin A., Milyagin V., Mintale I., Persson O., Ramos R., Rogoza A., Ryliskyte L., Scuteri A., Sirenko Y., Soulis G., Tasic N., Udovychenko M., Urazalina S., Wohlfahrt P., Zelveian P., Benetos A., Asmar R., De La Sierra A.
Journal of Hypertension. Vol. 36. 2018. P. 824-833