Comparative effects of meso-2,3-dimercaptosuccinic acid, monensin and salinomycin on the concentrations of cadmium and some essential elements in skeletal muscles of Cd-exposed mice

Cadmium (Cd) is an environmental pollutant shown to induce multi organ dysfunction. In this study we present novel data about the effects of meso-2,3-dimercaptosuccinic acid (DMSA), monensin and salinomycin on the concentration of Cd in skeletal muscles of mice exposed to Cd (II) acetate treatment for 14 days. The impact of Cd and the chelating agents on the endogenous concentrations of calcium (Ca), copper (Cu), iron (Fe), magnesium (Mg), phosphorous (P), selenium (Se) and zinc (Zn) was also investigated. Subacute exposure of mice to Cd (II) acetate resulted in a significant accumulation of the toxic metal ion in the skeletal muscles compared to the untreated controls. Salinomycin most effectively mobilized Cd from the muscles compared to DMSA and monensin. The Cd exposure and the tested chelating agents did not significantly alter the endogenous concentrations of the selected essential elements in mouse muscles. The presented results confirmed that among the tested chelating agents salinomycin is superior as a potential antidote to Cd poisoning. © 2018 Elsevier GmbH

Authors
Gluhcheva Y.1 , Kamenova K.2 , Dorkov P.3 , Lobanova Y. 4 , Skalnaya M. 4 , Ivanova J.5
Publisher
Elsevier GmbH
Language
English
Pages
596-600
Status
Published
Volume
50
Year
2018
Organizations
  • 1 Institute of Experimental Morphology, Pathology and Anthropology with Museum – BAS, Acad. Georgi Bonchev Str., bl.25, Sofia, 1113, Bulgaria
  • 2 Faculty of Chemistry and Pharmacy, Sofia University “St. Kliment Ohridski”, Bourchier Blvd. N1, Sofia, 1164, Bulgaria
  • 3 Chemistry Department, R&D, BIOVET JSC, 39 Peter Rakov Str., Peshtera, 4550, Bulgaria
  • 4 Peoples’ Friendship University of Russia (RUDN University), Miklukho-Maklai str. 6, Moscow, 117198, Russian Federation
  • 5 Faculty of Medicine, Sofia University “St. Kliment Ohridski”, Kozjak Street N1, 1407-Sofia, Bulgaria
Keywords
Cadmium; Chelating agents; Essential elements; Homeostatsis; Skeletal muscles
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/6380/
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