Polymorphism of Angiotensinogen T174M Gene and Cardiovascular Diseases in the Moscow Population

The groups of patients with myocardial infarction (MI) and hypertrophy of the left ventricle (HLV) (n = 45 and n = 53, respectively) and a sample of healthy individuals from the Moscow population (n = 60) were examined for T174M polymorphism of ACT gene (replacement of methionine for threonine at position 174 of the correspondent amino acid sequence). In MI patients the content of 7T genotypes and 7 allele was significantly lower than in the control group (57.8% against 80% and 67.9 against 89.2%, respectively), whereas the proportion of M allele and TM hétérozygotes was increased (32.1 against 10.8% and 37.8 against 18.3%, respectively). In patients with HLV, the proportion of 7T genotype (64.2%) and T allele (77.4%) was also lower than in the control group, whereas the frequency of M allele was increased (22.6%). Our results suggest that the T174M polymorphism of ACT gene is associated with MI and HLV in the Moscow population.

Authors
Chistyakov D.A. 1 , Turakulov R.I.2 , Moiseev V.S. 2 , Nosikov V.V.2
Journal
Number of issue
8
Language
English
Pages
1160-1164
Status
Published
Volume
35
Year
1999
Organizations
  • 1 State Research Institute of Genetics, Selection of Industrial Microorganisms, Moscow 113545, Russian Federation
  • 2 Russian University of People Friendship, Moscow 117272, Russian Federation
Keywords
angiotensinogen; adult; article; case control study; female; genetic polymorphism; genetic predisposition; genetics; genotype; heart infarction; heart left ventricle hypertrophy; human; male; middle aged; Russian Federation; Adult; Angiotensinogen; Case-Control Studies; Female; Genetic Predisposition to Disease; Genotype; Humans; Hypertrophy, Left Ventricular; Male; Middle Aged; Moscow; Myocardial Infarction; Polymorphism, Genetic
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/522/