Cortical control of nociceptive transmission from the heart

Depriming effect of the cerebral cortex (predominantly of zones 1 and 2 of viscerosomatic sensitivity) on transmission of the cardiac afferent signals with a subcortical nociceptive component, which were provoked by electrical stimulation of the sinoatrial node of the heart conduction system, was established in experiments on cats. The agonist of opiate M-receptors morphine considerably potentiated the effect of cortical stimulation, while opiate receptor blocker naloxone antagonized it.

Authors
Churyukanov V.V. 1, 2 , Bilibin D.P. 1, 2 , Khodorovich N.A. 1, 2 , Shevelev O.A. 1, 2
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
12
Language
English
Pages
1206-1208
Status
Published
Link
External link
Volume
128
Year
1999
Organizations
  • 1 Department of Pharmacology, Therapeutic, and Medical Prophylactic Faculties, I. M. Sechenov Moscow Medical Academy, Moscow, Russian Federation
  • 2 Department of Pathological Physiology, Russian University of Peoples' Friendship, Moscow, Russian Federation
Keywords
Cerebral cortex; Descending control; Heart; Nociception
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/521/
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