Synthesis of furyl-, furylvinyl-, thienyl-, pyrrolinylquinazolines and isoindolo[2,1-a]quinazolines

A method for the synthesis of hydrogenated furyl-, furylvinyl-, thienyl-, and pyrrolinyl-substituted quinazolin-4-ones was developed. A possibility of the reaction of 2-furylquinazolines with maleic anhydride was demonstrated. A number of quinazolines obtained were subjected to a primary bioscreening on inhibition of acetylcholinesterase. © 2015 Springer Science+Business Media New York.

Authors
Zaytsev V.P. 1, 2 , Revutskaya E.L. 1 , Kuźmenko M.G. 1 , Novikov R.A. 3 , Zubkov F.I. 1 , Sorokina E.A. 1 , Nikitina E.V. 1 , Toze F.A.A. 4 , Varlamov A.V. 1
Journal
Russian Chemical Bulletin
Issue number
6
Language
English
Pages
1345-1353
State
Published
Link
External link
DOI
10.1007/S11172-015-1016-1
Volume
64
Year
2015
Organizations
  • 1 Peoples̈ Friendship University of Russia, 6 ul. Miklukho-Maklaya, Moscow, 117198, Russian Federation
  • 2 Shared Res. and Educ. Ctr. of Phys.-Chem. Studs. of New Materials, Substances, and Catalytic Systems, 3 ul. Ordzhonikidze, Moscow, 115419, Russian Federation
  • 3 V. A. Engeĺgardt Institute of Molecular Biology, Russian Academy of Sciences, 32 ul. Vavilova, Moscow, 119991, Russian Federation
  • 4 Department of Chemistry, University of Douala, Faculty of Sciences, PO Box 24157, Douala, Cameroon
Keywords
2-furylquinazolin-4-ones; anthranilamide; Diels-Alder reaction; inhibition of acetylcholinesterase; intra-molecular [2+4] cycloaddition; isoindolo[2,1-a]quinazolines
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