Fibre Chemistry.
Vol. 47.
2016.
P. 497-500
Expression of mesenchymal cellular markers in the endometrium in health and in proliferative uterine diseases
Objective. To reveal the mechanisms responsible for the development of proliferative endometrial diseases. Material and methods. The expression of cell-cycle regulatory genes, the invasive potential, and proliferative properties were estimated in the mesenchymal cells isolated from the endometrium in health and proliferative diseases (endometrial hyperplastic processes (EHP), adenomyosis (AM), and hysteromyoma (HM)). Results. A difference was found in the expression of the c-Met proto-oncogene and the cell-cycle inhibitor p16. The expression of p16 was absent in health and HM and was detected in all samples in EHP and AM; c-Met was revealed in health and HM; its expression was absent in EHP and AM. There were no differences in the expression of T-cadherin, urokinase and its receptor, MMP3 which were responsible for stromal remodeling and invasion. Conclusion. The expression of c-Met and p16 in the mesenchymal cells changes in proliferative endometrial diseases. © Bionika Media Ltd.
Authors
Anikina T.A.
1,
2,
3
,
Sysoeva V.Y.1,
4
,
Rubina K.A.1,
5
,
Radzinsky V.E.
2
Journal
Publisher
ООО «Бионика Медиа»
Number of issue
9
Language
Russian
Pages
79-86
Status
Published
Link
Year
2016
Organizations
- 1 Department of Biochemistry and Molecular Medicine, Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Lomonosovsky av. 31-5, Moscow, 119192, Russian Federation
- 2 Department of Obstetrics and Gynecology with Course of Perinatology, Peoples’ Friendship University of Russia, Mikluho-Maklaya str. 6, Moscow, 117198, Russian Federation
- 3 The Central Hospital, October Revolution str., 318, Kolomna, 140407, Russian Federation
- 4 Laboratory of Gene and Cell Technology, Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Lomonosovsky av. 31-5, Moscow, 119192, Russian Federation
- 5 Laboratory of Postgenomic Technologies, Faculty of Fundamental Medicine, M.V. Lomonosov Moscow State University, Lomonosovsky av. 31-5, Moscow, 119192, Russian Federation
Keywords
c-Met; Endometrium; Mesenchymal cells; p16; T-cadherin; Urokinase
Date of creation
19.10.2018
Date of change
19.10.2018
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