Tumor-association inflammation determines malignancyat brain gliomas.

It is known, that brain gliomas may progressing and become more malignant as comparison with in an initial stage. At the same time not take into account the decisive role of tumor - association inflammation (TAI), which accompanies gliomas growth and progression. It is quite possible, that exactly TAI promoting malignancy of tumor process. With the purpose of confirm or disprove this assumption, the sophisticated experiments was carry out with implantation glioma 101.8 cells into embryonic rat brains, in which inflammation is absence, and with combined cultivation in vitro rat normal embryonic cells with high malignant glioma 101.8 cells. It was reveal cytolysis of malignant glioma 101.8 cells to be in touch with embryonic cells in experiments vivo and in vitro. While after combined inoculations into adult brains death of rats was observed as a result of invasive tumor growth. Consequently, one of the main reasons of glioma malignancy is tumor-association inflammation, in the absence thereof high malignant glioma cells losing its malignancy.

Publisher
Research Journal of Pharmaceutical, Biological and Chemical Sciences
Number of issue
1
Language
English
Pages
2147-2151
Status
Published
Volume
7
Year
2016
Organizations
  • 1 The State institution A.P. Romodanov Institute of Neurosurgery NAMS of Ukraine, Kyiv, 04050, Ukraine
  • 2 Russian Peoples' Friendship University, Miklukho-Maklaya str., 8, Moscow, 117198, Russian Federation
Keywords
Cocultivation in vitro; Combined inoculation into embryonic brain; Lost of glioma cells malignancy; Rat brain glioma 101.8; Rat embryonic cells; Tumor-association inflammation
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/4224/
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