Molecular mechanisms of metabolic adaptation in liver to patological changes at toxic hepatitis

Possible molecular mechanisms underlying changes in catalytical properties of alcohol dehydrogenase (ADH) and lactate dehydrogenase (LDH) were studied at toxic hepatitis. The development of toxic hepatitis is accomanied by significant changes in the activity of ADH and LDH assayed in subcellular fractions and kinetic characteristics of these enzymes.This can result in an increase cellular level of acetylaldehyde and lactate which promotes the development of liver cirrosis.

Authors
Zimin Yu.V.1 , Syatkin S.P. 2 , Berezov T.T. 2
Number of issue
3
Language
Russian
Pages
351-352
Status
Published
Volume
47
Year
2001
Organizations
  • 1 Molecular Pathology Group, Res. Inst. Traumatology Orthopedics, Verkhne - Volzhskaya nab.18, Nizhniy Novgorod 603155, Russian Federation
  • 2 Department of Biochemistry, Schooll of Medicine, Russ. Peoples' Friendship University, Mikluho-Maklay St. 8, Moscow 117198, Russian Federation
Keywords
Alcohol dehydrogrenase; Hepatitis; Lactate dehydrogenase
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/358/