The study of immunological component in antitumor effect of Trypanosoma cruzi

The experiments with passive transfer of splenocytes obtained from animals immunized with Trypanosoma cruzi lysate revealed the role of cell-mediated component of the immunity in the antitumor effect of T. cruzi. The common features of T. cruzi antigens and tumor-specific antigens of Ehrlich's adenocarcinoma were demonstrated. These antigens were shown to have common epitopes with mammalian mucins. The oncoprotective effect was achieved by immunization with type II and III mucins and was reproduced after passive transfer of splenocytes from immunized animals. © Springer Science+Business Media, Inc. 2008.

Authors
Zenina A.V.1 , Kravtsov E.G. 1 , Tsetsegsaikhan B.1 , Yashina N.V. 1 , Dalin M.V. 1 , Karpenko L.P. 1 , Sheklakova L.A. 1 , Kallinikova V.D. 2
Journal
Bulletin of Experimental Biology and Medicine
Publisher
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Number of issue
3
Language
English
Pages
352-354
Status
Published
Link
External link
DOI
10.1007/s10517-008-0089-3
Volume
145
Year
2008
Organizations
  • 1 Department of Microbiology, Russian University of People Friendship, Moscow, Russian Federation
  • 2 Invertebrate Physiology Department, M. V. Lomonosov Moscow State University, Moscow, Russian Federation
Keywords
Antitumor activity; Ehrlich's adenocarcinoma; Immunocompetent cells; Trypanosoma cruzi
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/3063/
Share

Other records