Applied Physics.
2011.
P. 79-82
Investigation of antitumor substance from Trichoderma
The effect of L-lysine-α-oxidase from Trichoderma harzianum Rifai on the functional activity of T-lymphocytes was investigated. It was shown that in a dose of 35 units/kg administered parentally the enzyme had no suppressive effect on the T-lymphocyte functional activity. An inhibitory effect of L-lysine-α-oxidase on some indices of the macrophages functional activity was observed. L-Lyzine-α-oxidase had a selective lymphotropic action and showed no mytostatic activity, which is In favour of the enzyme vs. other antitumor agents.
Authors
Podboronov V.M.
1,
2
,
Kuzovnikov A.E.
1,
2
,
Zaitsev A.K.
1,
2
,
Smirnova I.P.
1,
2
,
Berezov T.T.
1,
2
Journal
Number of issue
9-10
Language
Russian
Pages
3-6
Status
Published
Link
Volume
56
Year
2011
Organizations
- 1 N.F.Gamaleya Research Institute of Epidemiology and Microbiology, Russian Academy of Medical Sciences, Moscow, Russian Federation
- 2 Russian University of the People's Friendship, Moscow, Russian Federation
Keywords
L-lysine-α-oxidase; T-lymphocytes; Trichoderma
Date of creation
19.10.2018
Date of change
19.10.2018
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Other records
Neurochemical Journal.
Vol. 5.
2011.
P. 301-305