Aromatization of IMDAF adducts in aqueous alkaline media

In this paper, we propose a simple synthesis of isoindoline-4-carboxylic acids by means of the aromatization of 3a,6-epoxyisoindoles in alkaline media. The method is facile from an experimental point of view: a short-term (0.5-2h) reflux of epoxyisoindoles in 5% aqueous solutions of alkali leads to the target products in 40-90% yields. The absence of by-products, ease of isolation of the target products and applicability to acidophobic group bearing substrates favorably distinguishes the proposed procedure from previously utilized acid-catalyzed methods. The proposed strategy has been successfully utilized for isoindole containing compounds and nuevamine-type alkaloids. © The Royal Society of Chemistry 2012.

Editors
-
Journal
Publisher
-
Number of issue
10
Language
English
Pages
4103-4109
Status
Published
Department
-
Number
-
Volume
2
Year
2012
Organizations
  • 1 Department of Organic Chemistry, Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, Russian Federation
Keywords
Alkaline media; Carboxylic acids
Date of creation
19.10.2018
Date of change
19.10.2018
Short link
https://repository.rudn.ru/en/records/article/record/2311/