2-BENZAZEPINE NITRONES PROTECT DOPAMINERGIC NEURONS AGAINST 6-HYDROXYDOPAMINE-INDUCED OXIDATIVE TOXICITY
Archiv der Pharmazie. Vol. 345. 2012. P. 598-609
Triazolo[1′,5′:1,2]pyrimido[4,5-d]azocines were synthesized by the tandem expansion of the tetrahydropyridine ring in tetrahydropyridotriazolopyrimidines by the action of activated alkynes. Under these conditions, triazolopyridopyrimidines benzylated at the nitrogen atom of the pyrimidine moiety undergo the Hofmann cleavage of the tetrahydropyridine ring to form 5-vinyltriazolo[1,5-a]pyrimidines. © 2012 Springer Science+Business Media New York.