THERMAL-STABILITY OF L-LYSINE-ALPHA-OXIDASE FROM TRICHODERMA SP

The irreversible thermal inactivation of L-lysine-alpha-oxidase is a process whose initial step is reversible denaturation, accompanied by irreversible aggregation of the denatured molecules. This process is complicated by dissociation of the L-lysine-alpha-oxidase molecules into subunits, followed by irreversible aggregation of individual subunits. The combination of these factors gives a complex law of the inactivation kinetics, which in general is the superposition of two second-order kinetic laws. On the basis of an analysis of the kinetic laws of inactivation of L-lysine-alpha-oxidase it is suggested that the dissociation of the enzyme molecules into individual subunits is a stabilizing factor, which substantially decelerates the process of thermal inactivation.

Авторы
LUKASHEVA E.V. , ZHUKOVSKII A.P. , SODA K. , BEREZOV T.T.
Журнал
Номер выпуска
6
Язык
Английский
Страницы
738-743
Статус
Опубликовано
Том
56
Год
1991
Ключевые слова
FUNGAL ENZYMES; ANTITUMOR ACTIVITY; THERMAL INACTIVATION; L-LYSINE OXIDASE
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/9743/