INFLUENCE OF LONG-TERM ADAPTATION TO HYPOXY ON THE OPEN-FIELD BEHAVIOR REACTIONS OF RATS WITH DIFFERENT TYPES OF BEHAVIOR
We studied the influence of long-term (30 days) adaptation to hypobaric hypoxy (daily lifting to 5000 m for 5 h) on behaviour of rats with different typological characteristics and levels of resistance to hypoxy. Correlation was ascertained between the resistance of rats to oxygen deficiency and the open field locomotor activity. Adaptation was shown to induce the state of increased anxiety in animals of all the groups under study. In rats with the low resistance to hypoxy adaptation led to increase of exploratory activity. In rats with high initial resistance hypoxic influences caused an increased extinction of orienting reaction at repeated testing in the open field as well as motor excitation increase. In animals with active and medial types of behaviour hypoxic influences increased exploratory activity. In animals with the medial behavioural type increased exploratory activity was changed later by general motor excitation. In rats with the passive type of behaviour adaptation resulted in decrease of the number of rearings testifying to suppression of exploratory reactions, and in the phase changes of locomotor activity.
Бюллетень экспериментальной биологии и медицины
Клеточные технологии в биологии и медицине.
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук.