Molecular Basic of Pharmacotherapy of Cytokine Imbalance as a Component of Intervertebral Disc Degeneration Treatment

Intervertebral disc degeneration (IDD) and associated conditions are an important problem in modern medicine. The onset of IDD may be in childhood and adolescence in patients with a genetic predisposition. With age, IDD progresses, leading to spondylosis, spondylarthrosis, herniated disc, spinal canal stenosis. One of the leading mechanisms in the development of IDD and chronic back pain is an imbalance between pro-inflammatory and anti-inflammatory cytokines. However, classical therapeutic strategies for correcting cytokine imbalance in IDD do not give the expected response in more than half of the cases. The purpose of this review is to update knowledge about new and promising therapeutic strategies based on the correction of the molecular mechanisms of cytokine imbalance in patients with IDD. This review demonstrates that knowledge of the molecular mechanisms of the imbalance between pro-inflammatory and anti-inflammatory cytokines may be a new key to finding more effective drugs for the treatment of IDD in the setting of acute and chronic inflammation.

Shnayder Natalia A.1, 2 , Ashkhotov Azamat V.1 , Trefilova Vera V.3 , Nurgaliev Zaitun A.1, 3 , Novitsky Maxim A.3 , Petrova Marina M.2 , Narodova Ekaterina A.2 , Al-Zamil Mustafa 4 , Chumakova Galina A.5 , Garganeeva Natalia P.6 , Nasyrova Regina F.1, 7
Номер выпуска
  • 1 Institute of Personalized Psychiatry and Neurology, Shared Core Facilities, V.M. Bekhterev National Medical Research Centre for Psychiatry and Neurology, 192019 Saint Petersburg, Russia
  • 2 Shared Core Facilities “Molecular and Cell Technologies”, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, 660022 Krasnoyarsk, Russia
  • 3 Department of Neurology, Hospital for War Veterans, 193079 Saint Petersburg, Russia
  • 4 Department of Physiotherapy, Faculty of Continuing Medical Education, Peoples’ Friendship University of Russia, 117198 Moscow, Russia
  • 5 Department of Therapy and General Medical Practice with a Course of Postgraduate Professional Education, Altai State Medical University, 656038 Barnaul, Russia
  • 6 Department of General Medical Practice and Outpatient Therapy, Siberian State Medical University, 634050 Tomsk, Russia
  • 7 International Centre for Education and Research in Neuropsychiatry, Samara State Medical University, 443016 Samara, Russia
Ключевые слова
cytokine; cytokine status; chronic inflammation; intervertebral disc degeneration; molecular mechanism; treatment
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Другие записи

Shnayder Natalia A., Grechkina Violetta V., Trefilova Vera V., Efremov Ilya S., Dontceva Evgenia A., Narodova Ekaterina A., Petrova Marina M., Soloveva Irina A., Tepnadze Liia E., Reznichenko Polina A., Al-Zamil Mustafa, Altynbekova Gulnara I., Strelnik Anna I., Nasyrova Regina F.
Biomedicines. MDPI AG. Том 11. 2023. 1499 с.