Alzheimer's peptides A beta 1-40 and A beta 1-28 inhibit the plasma cholesterol esterification rate.

The amyloid fibrils of Alzheimer's disease and Down's syndrome amyloid deposits are composed mainly of aggregated amyloid beta protein (A beta) which also exists in a soluble form. It has been shown that both Alzheimer's disease and Down's syndrome share another common feature: the decrease in plasma cholesterol esterification in affected individuals. In the present work the effect of synthetic peptides A beta 1-40 and A beta 1-28 on normal human plasma cholesterol esterification rate was studied. Both peptides at a concentration of 1 ng/ml inhibited plasma cholesterol esterification rate to 40-50% of control value. Statistical analysis showed no differences in the effect of A beta 1-40 and A beta 1-28 on the inhibition, suggesting the importance of A beta sequence 1-28 for this effect.

Номер выпуска
4
Язык
Английский
Страницы
747-752
Статус
Опубликовано
Том
38
Год
1996
Ключевые слова
amyloid beta protein; Alzheimer's disease; Down's syndrome; lecithin-cholesterol acyltransferase; cholesterol esterification; reverse cholesterol transport; high density lipoproteins; amyloidogenesis
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/9370/