The Thioredoxin System of Mammalian Cells and Its Modulators

Oxidative stress involves the increased production and accumulation of free radicals, peroxides, and other metabolites that are collectively termed reactive oxygen species (ROS), which are produced as by-products of aerobic respiration. ROS play a significant role in cell homeostasis through redox signaling and are capable of eliciting damage to macromolecules. Multiple antioxidant defense systems have evolved to prevent dangerous ROS accumulation in the body, with the glutathione and thioredoxin/thioredoxin reductase (Trx/TrxR) systems being the most important. The Trx/TrxR system has been used as a target to treat cancer through the thiol–disulfide exchange reaction mechanism that results in the reduction of a wide range of target proteins and the generation of oxidized Trx. The TrxR maintains reduced Trx levels using NADPH as a co-substrate; therefore, the system efficiently maintains cell homeostasis. Being a master regulator of oxidation–reduction processes, the Trx-dependent system is associated with cell proliferation and survival. Herein, we review the structure and catalytic properties of the Trx/TrxR system, its role in cellular signaling in connection with other redox systems, and the factors that modulate the Trx system.

Журнал
Издательство
MDPI AG
Номер выпуска
7
Язык
Английский
Страницы
1757
Статус
Опубликовано
Том
10
Год
2022
Организации
  • 1 T.T. Berezov Department of Biochemistry, Peoples’ Friendship University of Russia (RUDN University)
  • 2 Laboratory of Molecular Oncobiology, Institute of Gene Biology, Russian Academy of Sciences
  • 3 Laboratory of Tumor Cell Death, Blokhin National Medical Research Center of Oncology
Ключевые слова
thioredoxin system; structure and catalytic function; inhibitors and activators; redox regulation; apoptosis
Дата создания
21.09.2022
Дата изменения
21.09.2022
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/93076/
Поделиться

Другие записи