Electrospinning of Fiber Matrices from Polyhydroxybutyrate for the Controlled Release Drug Delivery Systems

The submission provides an overview of current state of the problem and authors’ experimental data on manufacturing nonwoven fibrous matrices for the controlled release drug delivery systems (CRDDS). The choice of ultrathin fibers as effective carriers is determined by their characteristics and functional behavior, for example, such as a high specific surface area, anisotropy of some physicochemical characteristics, spatial limitations of segmental mobility that are inherent in nanosized objects, controlled biodegradation, and controlled diffusion transport. The structural-dynamic approach to the study of the morphology and diffusion properties of biopolymer fibers based on polyhydroxybutyrate (PHB) is considered from several angles. In the submission, the electrospinning (ES) application to reach specific characteristics of materials for controlled release drug delivery is discussed.

Авторы
Olkhov A.A.2, 3 , Karpova S.G. 5 , Bychkova A.V.5 , Vetcher A.A. 1, 4 , Iordanskii A.L.2
Издательство
IntechOpen
Язык
Русский
Статус
Опубликовано
Год
2022
Организации
  • 1 Российский университет дружбы народов
  • 2 N.N. Semenov Federal Research Center for Chemical Physics, Russian Academy of Sciences
  • 3 Plekhanov Russian University of Economics
  • 4 Complementary and Integrative Health Clinic of Dr. Shishonin
  • 5 Emanuel Institute of Biochemical Physics of Russian Academy of Sciences
Ключевые слова
polymer therapeutic systems; electrospinning; biopolymer fibers; nonwoven fibrous matrices; polyhydroxybutyrate; controlled diffusion transport; controlled release; morphology; segmental mobility
Дата создания
18.07.2022
Дата изменения
18.07.2022
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/90521/
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