The purpose of this paper is to explore the mechanism for manufacturing enterprises to achieve organizational innovation. The existing research few further in-depth studies can be done in combination with cases and lack of mechanisms and models to explore the integrated organization innovation of manufacturing enterprises. Based on innovation management theory and theoretical research on organizational management, organizational design and organizational change models, this article takes Midea Group as study subjects, to analyze the current situation, existing problems of Midea Group from the angle of organizational innovation. Through the in-depth case analysis of Midea Group s organizational innovation, this research has the following main findings: The organizational innovation of Midea Group is a systematic project. Organizational cultural innovation, information technology innovation, process innovation, and organizational structure innovation are closely related, and together form an indivisible and unified whole. The organizational culture innovation of Midea Group makes a significant contribution to the entire organizational innovation. The process innovation based on the "T+3 model, the organizational structure innovation of the "789 Project", and the information technology innovation by means of digital transformation have improved Midea Group's competence to respond quickly to customers and the market. The organizational culture innovation based on equity incentives unifies the goals and visions of the company and employees, and firmly binds core technical personnel and mid to high-end management personnel. This research can provide concrete case study for entrepreneurs to realize the stable development of manufacturing enterprises.