Efficiency and safety of terlipressin application during caesarian section in pregnant women with a high risk of bleeding: a multicenter comprehensive cohort study of Terli-Bleed. Part III

The search for new means of prevention and treatment of massive obstetric haemorrhage is a priority task for the world scientific community, both obstetricians and anesthesiologists. Previously, we have shown the preventive efficiency of terlipressin, which helps to reduce the volume of blood loss during caesarean section (CS), and its lack of systemic hemodynamic effects when used topically. Objective. To evaluate changes in clinical and laboratory parameters when using terlipressin topically as a means of preventing postpartum haemorrhage during CS in high-risk pregnant women. Patients and methods. This publication is a continuation of our multicenter comprehensive cohort study of Terli-Bleed. The study included 454 pregnant women at high risk for haemorrhage who delivered by CS. They were divided into two groups: a control group (n = 351) and a study group (n = 103), with topical administration of terlipressin injected into the myometrium. Complete blood count, acid-base balance, lactate and hemostasis parameters were analyzed. Results. The levels of hemoglobin, platelets, fibrinogen, lactate, and blood pH were different in the groups during the postoperative follow-up period (p < 0.05). Conclusion. The analysis of clinical and laboratory parameters indicates the preventive ability of terlipressin to reduce the volume of intra-and postoperative haemorrhage without affecting the hemostasis system. © 2021, Dynasty Publishing House. All rights reserved.

Raspopin Yu.S.1, 2, 12 , Shifman E.M. 3 , Belinina A.A.4 , Rostovtsev A.V.5 , Artymuk N.V.6 , Olenev A.S. 7, 8 , Tskhay V.B.2, 9 , Alexandrovich Yu.S.10 , Molchanova I.V.4 , Novikova O.N.6 , Pylaeva N.Yu.11
Dynasty Publishing House
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  • 1 Regional Clinical Center for Maternity and Childhood Protection, Krasnoyarsk, Russian Federation
  • 2 V.F.Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, Russian Federation
  • 3 M.F.Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russian Federation
  • 4 Altai Regional Clinical Perinatal Center, Barnaul, Russian Federation
  • 5 City Clinical Hospital of Emergency Medical Care No 8, Voronezh, Russian Federation
  • 6 Kemerovo State Medical University, Kemerovo, Russian Federation
  • 7 City Clinical Hospital No 24, Moscow, Russian Federation
  • 8 Institute of Medicine, Peoples' Friendship University of Russia, Moscow, Russian Federation
  • 9 Federal Medical-Biological Agency of Russia, Moscow, Russian Federation
  • 10 Saint Petersburg State Pediatric Medical University, Saint Petersburg, Russian Federation
  • 11 V.I.Vernadsky Crimean Federal University, Simferopol, Russian Federation
  • 12 2A Academician Kirenskу str, Krasnoyarsk, 660074, Russian Federation
Ключевые слова
Caesarean section; Clinical and laboratory parameters; Postpartum haemorrhage; Terlipressin
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