Systemic Essential Metal and Metalloid Levels in Patients with Benign Breast Disease and Breast Cancer

The objective of the present study is evaluation of serum and hair levels of essential metals and metalloids in women with benign breast disease and breast cancer in order to define similar and distinct patterns that may mediate the link between these pathologies. A total of 310 adult women aged 20–80 years old were enrolled in the present study. Of those, 103 patients had benign (fibrocystic) breast disease, 107 patients had breast cancer (stage II), and 100 women were healthy and with absence of breast pathology. Trace metal and metalloid levels in hair and serum were evaluated by inductively coupled argon plasma mass-spectrometry (ICP-MS). The data demonstrate that breast cancer patients were characterized by significantly higher hair Cr and V levels, as well as reduced Cu and Mn content as compared to both benign breast disease patients and controls. In contrast, serum Cu levels in women with breast cancer exceeded those in the controls and benign breast disease cases. Patients with both benign and malignant breast tumors were characterized by lower serum Mn levels as compared to the control values. Serum Cu/Zn and especially Cu/Mn were found to be significantly increased in cancer patients. Significantly reduced hair and serum Se levels were noted only in women with fibrocystic disease. Based on the analysis of two biosamples, it is proposed that malignant breast tumor development is associated with the reduction of systemic Mn and Zn levels, and a concomitant elevation of Cu concentrations. © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Skalny A.V. 1, 2 , Sekacheva M.I.1 , Aschner M. 3, 4 , Lobanova Y.N. 5 , Tinkov A.A. 3, 6
Humana Press Inc.
  • 1 World-Class Research Center “Digital Biodesign and Personalized Healthcare”, IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119435, Russian Federation
  • 2 Department of Bioelementology, KG Razumovsky Moscow State University of Technologies and Management, Moscow, 109004, Russian Federation
  • 3 Laboratory of Molecular Dietetics, IM Sechenov First Moscow State Medical University (Sechenov University), Moscow, 119435, Russian Federation
  • 4 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, United States
  • 5 Department of Medical Elementology, RUDN University, Moscow, 117198, Russian Federation
  • 6 Laboratory of Ecobiomonitoring and Quality Control, Yaroslavl State University, Yaroslavl, 150003, Russian Federation
Ключевые слова
Breast tumors; Carcinogenesis; Copper; Fibrocystic disease; Manganese
Дата создания
Дата изменения
Постоянная ссылка

Другие записи