Radiation therapy, chemotherapy or surgery is recommended for early treatment of head and neck cancers according to current standards. Radiation and chemoradiation therapy of head and neck tumors leads to the development of acute and chronic radiation complications in the oral cavity. Objective: to conduct a qualitative assessment of saliva by crystallography in patients receiving chemoradiation therapy for head and neck neoplasms. In the period from 2020 to 2021, 50 patients with oral mucositis of varying severity were examined, who received antitumor treatment at the Russian Scientific Center for Roentgenoradiology (RSCRR). Separation of patients: in the I group, dental support was carried out in the form of correcting the skills of individual oral hygiene. In the II group were used prolongedaction herbal preparations toothpaste based. The results were evaluated using saliva crystallography and oral hygiene. The obtained results of saliva crystallography prove the effectiveness of the use of prolongedaction herbal preparations in patients with oral mucositis of varying severity, receiving chemoradiation therapy. The advantage of morphological analysis of salivary facies is simplicity, non-invasiveness and is an inexpensive way to assess the health of the oral cavity © 2022. Journal of International Dental and Medical Research.All Rights Reserved.