Estimation of the prevalence of HPV-positive squamous cell carcinoma of the oropharynx on the example of a separate sample in the Russian Federation [Оценка распространенности ВПЧ-положительного плоскоклеточного рака ротоглотки на примере отдельной выборки в Российской Федерации]

Introduction. The increasing incidence of oropharyngeal squamous cell carcinoma observed globally in recent decades gave rise to research in this area. In 2005, human papillomavirus was proved to be an etiological factor of oropharyngeal squamous cell carcinoma. Currently, oropharyngeal squamous cell carcinoma associated with human papillomavirus is believed to have some unique characteristics. The analysis of oropharyngeal squamous cell carcinoma epidemiology appears to be highly relevant. Objective - to assess the incidence and prevalence of oropharyngeal squamous cell carcinoma associated with human papillomavirus in Russia on the example of a certain sample of patients. Materials and methods. We analyzed medical records of 199 oropharyngeal squamous cell carcinoma patients treated in N.N. Blokhin Russian Cancer Research Center between 2016 and 2021. We analyzed the frequency of tumors associated with human papillomavirus, age, sex, tumor spread and stage depending on р16 status. Results. More than half of the patients from our cohort (58.3 %) were р16-positive. The peak incidence was observed in individuals aged 45 to 64 years (more than 60 % of cases). Males were twice as likely to have р16-positive tumors than females. A total of 60.9 % of patients with р16-positive tumors had stage I disease, whereas 51.2 % of patients with p16-negative tumors had stage IV disease. Conclusion. The results obtained for a sample of Russian patients are comparable with the findings of foreign authors. © 2022 Opuholi Golovy i Sei. All rights reserved.

Авторы
Pkheshkhova B.G. 1, 2 , Mudunov A.M. 3, 4 , Azizyan R.I.1 , Pak M.B.3 , Ishchenko K.B.1
Номер выпуска
1
Язык
Русский
Страницы
72-78
Статус
Опубликовано
Том
12
Год
2022
Организации
  • 1 N.N. Blokhin Russian Cancer Research Center, Ministry of Health of Russia, 24 Kashirskoe Shosse, Moscow, 115478, Russian Federation
  • 2 Peoples' Friendship University of Russia, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 3 Lapino Clinical Hospital, 111 1st Uspenskoe Shosse, Lapino Village, Odintsovo Dst., Moscow Region43081, Russian Federation
  • 4 Department of Oncology of I.M. Sechenov First Moscow State Medical University of Healthcare of the Russian Federation, Bld. 2, 8 Trubetskaya St., Moscow, 119991, Russian Federation
Ключевые слова
head; human papillomavirus; neck tumors; oropharyngeal squamous cell carcinoma; p16
Дата создания
06.07.2022
Дата изменения
06.07.2022
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/83980/
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