Buccal Micronucleus Cytome Assay for the Evaluation of Cytogenetic Status of Healthcare Professionals Contacting with Anti-Cancer Drugs

Abstract: Healthcare professionals of chemotherapy departments are in a regular contact with anticancer drugs that have genotoxic properties. The analysis of the cytogenetic status of healthcare professionals (54 individuals) was for the first time carried out using a new promising noninvasive method, buccal micronucleus cytome assay with the calculation of integral indices. The effect was estimated with different duration of exposure to chemotherapy drugs (after an employee’s vacation, one month after vacation, and before vacation). Statistically significant increases in almost all studied indices of cytogenetic damages, proliferation, and apoptosis as compared with the control group of office staff (47 individuals) were detected. Among healthcare professionals, an increase in the portion of individuals with an increased level of cytogenetic abnormalities with the maximum exposure duration from 24 to 38% (11% in the control) was established. Among cancer patients (9 individuals), the portion of individuals with a high level of cytogenetic abnormalities was 56% before the next course of chemotherapy and 87% after it. © 2022, Pleiades Publishing, Inc.

Kirsanov K.I. 1, 2 , Sycheva L.P.3 , Lesovaya E.A.1, 4 , Zhidkova E.M.1 , Vlasova O.A.1 , Osipova A.V. 1, 5 , Lylova E.S.1 , Grigorieva D.D.1 , Kulakova E.M.1 , Solenova L.G.1 , Belitsky G.A. 1 , Mikhaylova I.N.1 , Yakubovskaya M.G. 1
Номер выпуска
  • 1 Blokhin National Medical Research Center of Oncology, Moscow, 115478, Russian Federation
  • 2 Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 3 Burnazyan Federal Medical Biophysical Center of Federal Medical Biological Agency, Moscow, 123182, Russian Federation
  • 4 Pavlov Ryazan State Medical University, Ryazan, 390026, Russian Federation
  • 5 Loginov Moscow Clinical Scientific Center, Moscow, 111123, Russian Federation
Ключевые слова
anticancer drugs; buccal micronucleus cytome assay; cytogenetic damages; healthcare professionals of chemotherapy departments; patients with cancer
Дата создания
Дата изменения
Постоянная ссылка

Другие записи

Osikov M.V., Davydova E.V., Kaigorodtseva N.V., Fedosov A.A., Il’inykh M.A., Savchuk K.S., Vorgova L.V.
Бюллетень экспериментальной биологии и медицины Клеточные технологии в биологии и медицине. New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук. Том 173. 2022. С. 24-27