The main objective of the paper is to obtain sharp Lipschitz type estimates for the norm of operator differences (Formula presented.) for pairs (Formula presented.) and (Formula presented.) of commuting maximal dissipative operators. To obtain such estimates, we use double operator integrals with respect to semi-spectral measures associated with the pairs (Formula presented.) and (Formula presented.). Note that the situation is considerably more complicated than in the case of functions of two commuting contractions and to overcome difficulties we had to elaborate new techniques. We deduce from the main result Hölder type estimates for operator differences as well as their estimates in Schatten–von Neumann norms. © 2022 Wiley-VCH GmbH.