Alzheimer's peptides Aβ1-40 and Aβ1-28 inhibit the plasma cholesterol esterification rate

The amyloid fibrils of Alzheimer's disease and Down's syndrome amyloid deposits are composed mainly of aggregated amyloid beta protein (Aβ) which also exists in a soluble form. It has been shown that both Alzheimer's disease and Down's syndrome share another common feature: the decrease in plasma cholesterol esterification in affected individuals. In the present work the effect of synthetic peptides Aβ1-40 and Aβ1-28 on normal human plasma cholesterol esterification rate was studied. Both peptides at a concentration of 1 ng/ml inhibited plasma cholesterol esterification rate to 40-50% of control value. Statistical analysis showed no differences in the effect of Aβ1-40 and Aβ1-28 on the inhibition, suggesting the importance of Aβ sequence 1-28 for this effect.

Авторы
Редакторы
-
Издательство
-
Номер выпуска
4
Язык
Английский
Страницы
747-752
Статус
Опубликовано
Подразделение
-
DOI
-
Номер
-
Том
38
Год
1996
Организации
  • 1 Department of Pathology, New York University Medical Center, 560 First Avenue, TH427, New York, NY 10016, United States
  • 2 Department of Medicine, New York University Medical Center, 560 First Avenue, TH427, New York, NY 10016, United States
  • 3 Department of Biochemistry, Russ. Peoples' Friendship University, Miklucho-Maklay St., 8, Moscow 117198, Russian Federation
Ключевые слова
Alzheimer's disease; Amyloid beta protein; Amyloidogenesis; Cholesterol esterification; Down's syndrome; High density lipoproteins; Lecithin-cholesterol acyltransferase; Reverse cholesterol transport
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/809/