Monitoring the Efficacy of Treatment in Children with Risk of Asthma

Asthma is the most common chronic disease of childhood throughout the world including Georgia. The tendency of substantial increase of its prevalence and severe progression is being mentioned. Prevention of the disease, as well as effective diagnostic and treatment methods have great importance for managing this problem. The modern approaches in the prevention and treatment of asthma are delivered by GINA, "Global Strategy for Asthma Management and Prevention". The main recommendations of this initiative have already been using in different countries with consideration of national peculiarities. Using leukotriene inhibitors during obstruction of respiratory system is one of the main recommendations of the project. The cysteinyl leukotrienes, LTC4, LTD4, and LTE4, play an integral role in pathophysiology of asthma [4, 7]. The unique mechanism of leukotriene receptor antagonists (LTRA) action results in a combination of both bronchodilator and anti-inflammatory effects [4. 9]. Considering the fact that optimal place of these drugs in asthma management is still under review, our work implies the monitoring of effectiveness of treatment with Montelukast, as one of the leukotrien receptor antagonist.