EVALUATION OF THE CORTICOSTEROID RECEPTORS' LEVEL IN THE KIDNEYS OF RATS AFTER SYSTEMIC ISCHEMIA-REPERFUSION

BACKGROUND: With disturbance of the systemic blood supply, the body experiences hypoxia and stress. Under stress of any etiology, there is a non-specific rearrangement ofphysiological and biochemical processes. These processes occur under the influence of corticosteroid hormones. AIM: To determine the level of corticosteroid receptors in the kidneys of rats at different times after systemic ischemia-reperfusion. METHODS: The study included 80 male white rats. All the animals were divided into 2 groups. A model of systemic ischemia-reperfusion was created in the main group (n=70). Further, on 1, 3, 5, 7, 14, 21 and for 35 days, we determined the level of gluco - and mineralocorticoid receptors in the kidneys. RESULTS: In the animals of the main group, we observed a short-term period (during the first 3 days) of a decrease in the content of both glucorticoid (p<0.05) and mineralocorticoid (p<0.01) receptors. The dynamics of recovery of the level of corticosteroid receptors was 3 times faster than that of mineralocorticoid receptors. CONCLUSIONS: The dynamics of corticosteroid receptors' level in the kidneys of rats after ischemia caused by an arrest of systemic circulation show the recovery time after ischemia-reperfusion injury, which ensures the stability of an individual to hypoxia.

Авторы
Bayburina G.1 , Nurgaleeva E.1 , Samigullina A.1 , Farshatova E.1 , Agletdinov E.1 , Tarasova T.2 , Mosina L. 2 , Ryzhakin S. 3 , Khaydar D. 3
Журнал
Издательство
European Scientific Society
Номер выпуска
2
Язык
Английский
Страницы
23-25
Статус
Опубликовано
Том
11
Год
2021
Организации
  • 1 Bashkir State Med Univ, Ufa, Bashkortostan, Russia
  • 2 Natl Res Ogarev Mordovia State Univ, Saransk, Russia
  • 3 Peoples Friendship Univ Russia, RUDN Univ, Moscow, Russia
Ключевые слова
glucocorticoid receptors; mineralocorticoid receptors; resistance to hypoxia; ischemia-reperfusion injury
Дата создания
16.12.2021
Дата изменения
16.12.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/77556/
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