Distribution of polymorphic marker of genes of the renin-angiotensin system RAS (AGT, AGTR1, АСЕ), ITGB3, PPARG) in patients with essential arterial hypertension depending on the nature of the nocturnal decrease of BP

A clinical-genetic study using ABPM (24-hour BP monitoring) and Holter’s ECG methods in 49 patients with essential arterial hypertension (group 1: 17 patients without sufficient nocturnal BP decrease СI≤10%, and group 2: 32 patients with sufficient nocturnal BP decrease СI≥10%,) was performed for comparative analysis of the genotype frequencies of ACE, AGT, AGTR1, ITGB3, and PPARG. The study was conducted in order to clarify the pathogenetic mechanisms of the implementation of different dynamics of nocturnal blood pressure in patients with hypertension without metabolic syndrome. It was found that in group 1, protective genotype II of the ACE gene was more common (p ≤ 0.025) than in the population data. A significant increase (p ≤ 0.025) in the frequency of the CC genotype of the AGTR1 gene responsible for the formation of insulin resistance compared to the population data was combined with a significant increase in the frequency of autonomic dysfunction in patients of group 1 - 83.4% vs. 64.5% group 2 respectively. The results obtained indicate the possible pathogenetic links between genetically determined insulin resistance and autonomic nervous system dysfunction and allows us to determine therapeutic approaches for correcting the nocturnal blood pressure profile. © 2021 North Atlantic University Union NAUN. All rights reserved.