A Three-Component Synthesis of 3-Functionally Substituted 5,6-Dihydropyrrolo[2,1-a]isoquinolines

Synthesis of novel C3-substituted 5,6-dihydropyrrolo[2,1-a]isoquinolines via a three-component domino reaction of 1-aroyl-3,4-dihydroisoquinolines, terminal alkynes and CH-acids under microwave irradiation in dry acetonitrile is described. The method developed enables the obtainment of highly functionalized compounds with pharmacophore groups, which are potentially biologically active. © 2021 Wiley-VHCA AG, Zurich, Switzerland

Издательство
Wiley-VCH Verlag
Язык
Английский
Статус
Опубликовано
Год
2021
Организации
  • 1 Organic Chemistry Department, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation
  • 2 N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 47 Leninsky Prosp., Moscow, 119991, Russian Federation
Ключевые слова
CH-acids; domino reaction; pyrrolo[2,1-a]isoquinolines; terminal alkynes; three-component reactions
Дата создания
16.12.2021
Дата изменения
16.12.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/76861/
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