Organic synthesis via Kolbe and related non-Kolbe electrolysis: An enabling electro-strategy

An efficient and environmentally friendly synthetic methodology is preferred over conventional methods that require expensive chemicals & oxidants to achieve value-added organic transformations. Electrochemical conversions encounter conventional shortcomings and introduce easy scale-up methods to synthesize complex and hindered molecules employing electricity as a clean reagent and catalyzing entity. Electrochemical conditions minimize waste formation and increase the chances of getting the maximum amount of target products under ambient conditions. The Kolbe and related non-Kolbe electrolysis process where the anodic oxidation of carboxylic acids leads to decarboxylation can be used intelligently to form new bonds and achieve value-added molecules and stereoselective products. The memory of chirality, where we have contributed to, is a more fascinating strategy to achieve highly desired asymmetric products via electrochemical decarboxylation (ED). Besides this, coupling (homo, hetero), dimerization, addition, cyclization, and CH activation via ED are also significant aspects of this strategy. Flow electrochemistry and photochemistry using the ED strategy could enhance the selectivity and product yield, avoiding overoxidation. Herein, we discussed several examples of ED and its applications to drive value-added transformations under mild, clean and sustainable conditions and also addressed mechanistic aspects. This ED approach will enable and provide inspiration for future applications in electro-organic synthesis. © 2021 The Royal Society of Chemistry.

Sbei N. 1, 2 , Aslam S.3 , Ahmed N.4, 5
Royal Society of Chemistry
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  • 1 Organic Chemistry Department, Peoples' Friendship University of Russia, RUDN University, 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 2 Institute of Nanotechnology, Karlsruhe Institute of Technology, Eggenstein-Leopoldshafen, Karlsruhe, 76344, Germany
  • 3 Department of Chemistry, Women University Multan, Multan, 60000, Pakistan
  • 4 International Centre for Chemical and Biological Sciences, HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan
  • 5 School of Chemistry, Cardiff University, Main Building Park Place, Cardiff, CF10 3AT, United Kingdom
Ключевые слова
Anodic oxidation; Carboxylation; Chemical activation; Electrochemistry; Electrolysis; Molecules; Organic chemicals; Stereochemistry; Conventional methods; Electro-organic synthesis; Electrochemical conditions; Electrochemical conversion; Mechanistic aspects; Memory of chiralities; Organic transformations; Synthetic methodology; Synthesis (chemical)
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