Self-Assembly and Multifaceted Bioactivity of a Silver(I) Quinolinate Coordination Polymer

Coordination polymers have emerged as a new class of potent biologically active agents due to a variety of important characteristics such as the presence of bioactive metal centers and linkers, low toxicity, stability, tailorable structures, and bioavailability. The research on intermediate metabolites has also been explored with implications toward the development of selective anticancer, antimicrobial, and antiviral therapeutic strategies. In particular, quinolinic acid (H2quin) is a recognized metabolite in kynurenine pathway and potent neurotoxic molecule, which has been selected in this study as a bioactive building block for assembling a new silver(I) coordination polymer, [Ag(Hquin)(μ-PTA)]n·H2O (1). This product has been prepared from silver oxide, H2quin, and 1,3,5-triaza-7-phosphaadamantane (PTA), and fully characterized by standard methods including single-crystal X-ray diffraction. Compound 1 has revealed distinctive bioactive features, namely (i) a remarkable antiviral activity against herpes simplex virus type 1 (HSV-1) and adenovirus 36 (Ad-36), (ii) a significant antibacterial activity against clinically important bacteria (Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa), and (iii) a selective cytotoxicity against HeLa (human cervix carcinoma) cell line. The present work widens a growing family of bioactive coordination polymers with potent antiviral, antibacterial, and antiproliferative activity. © 2021 American Chemical Society. All rights reserved.

Jaros S.W.1 , Krogul-Sobczak A.2 , Bażanów B.3 , Florek M.3 , Poradowski D.4 , Nesterov D.S. 5 , Śliwińska-Hill U.6 , Kirillov A.M. 5, 7 , Smoleński P.1
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  • 1 Faculty of Chemistry, University of Wroclaw, F. Joliot-Curie 14, Wrocław, 50-383, Poland
  • 2 Faculty of Chemistry, University of Warsaw, Pasteura 1, Warsaw, 02-093, Poland
  • 3 Department of Pathology, Wrocław University of Environmental and Life Sciences, Norwida 31, Wrocław, 50-375, Poland
  • 4 Department of Biostructure and Animal Physiology, Wrocław University of Environmental and Life Sciences, Kożuchowska 1, Wrocław, 51-631, Poland
  • 5 Centro de Química Estrutural and Departamento de Engenharia Química, Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais, Lisbon, 1049-001, Portugal
  • 6 Department of Analytical Chemistry, Faculty of Pharmacy, Wroclaw Medical University, Borowska 211 A, Wrocław, 50-566, Poland
  • 7 Research Institute of Chemistry, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya st., Moscow, 117198, Russian Federation
Ключевые слова
Biochemistry; Escherichia coli; Functional polymers; Lanthanum compounds; Metabolites; Self assembly; Silver oxides; Single crystals; Viruses; Active agents; Anti-bacterial activity; Antiviral activities; Bioactives; Coordination Polymers; Coordination-polymers; Intermediate metabolites; Low toxicity; Metal centres; Quinolinate; Cell culture
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