Candidate genes of regulation of skeletal muscle energy metabolism in athletes

All biological processes associated with high sports performance, including energy metabolism, are influenced by genetics. DNA sequence variations in such genes, single nucleotide variants (SNVs), could confer genetic advantages that can be exploited to achieve optimal athletic performance. Ignorance of these features can create genetic “barriers” that prevent professional athletes from pursuing a career in sports. Predictive Genomic DNA Profiling reveals single nucleotide variations (SNV) that may be associated with better suitability for endurance, strength and speed sports. (1) Background: To conduct a research on candidate genes associated with regulation of skeletal muscle energy metabolism among athletes. (2) Methods: We have searched for articles in SCOPUS, Web of Science, Google Scholar, Clinical keys, PubMed, e-LIBRARY databases for the period of 2010–2020 using keywords and keywords combinations; (4) Conclusions: Identification of genetic markers associated with the regulation of energy metabolism in skeletal muscles can help sports physicians and coaches develop personalized strategies for selecting children, teenagers and young adults for endurance, strength and speed sports (such as jogging, middle or long distance runs). However, the multifactorial aspect of sport performances, including impact of genetics, epigenetics, environment (training and etc.), is important for personalized strategies for selecting of athletes. This approach could improve sports performance and reduce the risk of sports injuries to the musculoskeletal system. © 2021 by the authors. Licensee MDPI, Basel, Switzerland.

Авторы
Balberova O.V.1 , Bykov E.V.1 , Medvedev G.V.2 , Zhogina M.A.2 , Petrov K.V.3 , Petrova M.M.3 , Al-Zamil M. 4 , Trefilova V.V. 5 , Goncharova P.S.6 , Shnayder N.A. 6, 7
Журнал
Издательство
MDPI
Номер выпуска
11
Язык
Английский
Статус
Опубликовано
Номер
1682
Том
12
Год
2021
Организации
  • 1 The Research Institute of Olympic Sports, Ural State University of Physical Culture, Chelyabinsk, 454091, Russian Federation
  • 2 Department of Hand Surgery with Microsurgical Equipment, Vreden National Medical Research Center of Traumatology and Orthopedics, St. Petersburg, 195427, Russian Federation
  • 3 Department of Physical and Rehabilitation Medicine with a Postgraduate Course, Professor V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russian Federation
  • 4 Department of Physiotherapy, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 5 The Neurological Department No. 16, The Hospital for War Veterans, St. Petersburg, 193079, Russian Federation
  • 6 Center of Personalized Psychiatry and Neurology, V.M. Bekhterev National Medical Research Center for Neurology and Psychiatry, Department of Personalized Psychiatry and Neurology, St. Petersburg, 192019, Russian Federation
  • 7 Shared Core Facilities Molecular and Cell Technologies, V.F. Voino-Yasenetsky Krasnoyarsk State Medical University, Krasnoyarsk, 660022, Russian Federation
Ключевые слова
Athlete; Candidate genes; Energy metabolism; Personalized medicine; Polymorphism; Single nucleotide variant; Skeletal muscles; Sports genetics
Дата создания
16.12.2021
Дата изменения
16.12.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/76529/
Поделиться

Другие записи