Chemistry of Functionalized Benzazepines. 5 [1]. Synthesis and Chemical Transformation of the 1,2,4,5-Tetrahydrospiro- [3H-2-benzazepine-3,1′-cycloalkanes]

The synthesis of new spire derivatives of tetrahydro-2-benzazepine was accomplished and their nitration, bromination, allylation, acetylation, formylation and oxidation reactions were studied. Nitration and bromination of 5-methyl(1,5-dimethyl)-1,2,4,5-tetrahydrospiro[3H-2-benzazepine-3,1′- cycloalkane] took place regioselectively on position C-8 of the phenyl ring. A nitrone was obtained for the first time in the title series. The structures of the compounds were established by ir and nmr spectroscopy.

Авторы
Kouznetsov V.1 , Alirio Palma R. , Salas S.1 , Vargas L.Y.1 , Zubkov F. 2 , Varlamov A. 2 , Martfnez J.R.1
Редакторы
-
Издательство
HeteroCorporation
Номер выпуска
5
Язык
Английский
Страницы
1591-1595
Статус
Опубликовано
Подразделение
-
Номер
-
Том
34
Год
1997
Организации
  • 1 Lab. de Sintesis Organ. Fina, Escuela de Química, Universidad Industrial de Santander, A. A. 678, Bucaramanga, Colombia
  • 2 Department of Organic Chemistry, Druzhby Narodov University, Ordzhonikidze Street 3, Moscow, Russian Federation
Ключевые слова
benzazepine derivative; cycloalkane derivative; acetylation; antiviral activity; article; central nervous system disease; depression; drug synthesis; drug transformation; nonhuman; psychosis
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/765/