Effect of L-lysine-α-oxidase on the synthesis of proteins associated with autoimmune pathologies in HIV infection

In HIV-infected MT-4 cells, L-lysine-α-oxidase, an inhibitor of HIV reproduction, selectively inhibits the synthesis of histone proteins, including 18K antigen (H2B histone). This protein is the target for autoimmune suppression of helper T cells. The enzyme has a low effect on the synthesis of other proteins and DNA. In addition to 18K antigen, L-lysine-α-oxidase suppresses the synthesis of high-molecular-weight proteins (270, 220, 140, 100, 75, 70, and 60 kD). ©1997 Plenum Publishing Corporation.

Авторы
Редакторы
-
Издательство
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
Номер выпуска
1
Язык
Английский
Страницы
30-32
Статус
Опубликовано
Подразделение
-
Номер
-
Том
123
Год
1997
Организации
  • 1 Department of Biochemistry, Russian University of Peoples' Friendship, Moscow, Russian Federation
  • 2 Institute of Viral Preparations, Russian Academy of Medical Sciences, Moscow, Russian Federation
Ключевые слова
18K antigen; HIV infection; L-lysine-α-oxidase; Protein synthesis
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/762/