The Characteristics of the Connective Tissue of the Pelvic Floor at the Collapse of the Genitals

The objective of our study is to clarify the distribution of immunohistochemical marker expression of MMP-1, MMP-2 and TIMP-1 in the sacrouterine and round ligaments of the uterus among women with genital prolapse. The research was performed on the material of biopsies of sacrouterine and round ligaments of the uterus on both sides taken during vaginal hysterectomy from 15 women with genital prolapse aged 42 to 65 years old. It was found that the decrease in the accumulation of TIMP-1 on the background of high expression of metalloproteinases in the POP contrasts with a moderate level of expression of MMP-2, low MMP-1 and moderate TIMP-1 in the control group, which affects the density of the VCR. Connective tissue loosening, reducing of its elasticity and tensile strength was accompanied by degradation of fibers and increased degradation of collagen, defining pathobiochemical disorders in the pelvic dysfunction.