Microwave-Assisted Cu(I)-Catalyzed Synthesis of Unsymmetrical 1,4-Diamino-2-butynes via Cross-A3-Coupling/Decarboxylative A3-Coupling

1,4-Diamino-2-butynes display both chemical and physiological properties. Here a highly efficient synthesis avenue to generate unsymmetric 1,4-diamino-2-butynes has been developed by microwave-assisted Cu(I)-catalyzed cross-A3-coupling/decarboxylative coupling of two different amines, formaldehyde, and propiolic acid through a domino process. This multicomponent reaction provides a series of target products in moderate to good yields with high chemoselectivity. © 2021 American Chemical Society.

Авторы
Xu X. 1 , Feng H.2 , Van Der Eycken E.V.
Статус
Опубликовано
Год
2021
Организации
  • 1 Laboratory for Organic and Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, Ku Leuven, Celestijnenlaan 200F, Leuven, 3001, Belgium
  • 2 College of Chemistry and Chemical Engineering, Shanghai Engineering Research Center of Textile Chemistry and Cleaner Production, Shanghai University of Engineering Science, Shanghai, 201620, China
  • 3 Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya Street, Moscow, 117198, Russian Federation
Дата создания
20.07.2021
Дата изменения
20.07.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/74468/
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