The state of the present environment is characterized by a significant increase of the anthropogenic impact. More and more territories on the planet, including Russia, have the influence of chemical pollution. The child’s body is especially sensitive to the effects of chemical pollution of the environment. Respiratory and cardiovascular systems are leading adaptive body systems. Therefore, today there is a question about degree of exposure to chemical pollutants on bodies of adolescents. Purpose of the study is to evaluate the functioning of cardiovascular and respiratory systems of adolescents exposed to chemical pollution of the environment. The study presents data of the anthropogenic effects impact on the cardiovascular and respiratory systems of the adolescents‘ bodies (15-17 years of age), living in conditions of environment’s chemical pollution (n = 222: 102 boys and 120 girls). As a control group, the study involved adolescents living in environmentally friendly conditions (n = 180: 90 boys and 90 girls). To assess the activity of the cardiovascular (CVS) and respiratory systems (RS), we used indicators of external respiration, blood pressure and the study of the hart’s functional intervals. A persistent effect of chemical pollutants on the cardiovascular and respiratory systems of adolescent organism was established as a result of data obtained. More significant changes were found in boys as compared to the girls. Considering the age-related dynamics of changes, we can conclude that maximum abnormalities occur at the peak of puberty in both – boys and girls (14, 16 and 13, 14 years, respectively), which can have negatively affect the further developmental. Copyright@ EM International.