Synthesis, X-ray structure and biological activity of mono- and dinuclear copper complexes derived from N-{2-[(2-diethylamino(alkyl)imino)-methyl]-phenyl}-4-methyl-benzenesulfonamide

A series of copper(II) complexes with new Schiff bases, namely N-{2-[(2-diethylamino(alkyl)imino)-methyl]-phenyl}-4-methylbenzenesulfonamide [alkyl = ethyl (HL1) or propyl (HL2)], were synthesized using copper acetate or chloride and characterized by elemental analysis, IR and X-ray absorption spectroscopy, and single-crystal X-ray diffraction. The coordination geometry around the Cu(II) ion in Cu(L1)2 and Cu(L2)2 was studied by X-ray absorption spectroscopy. The crystal structures of copper(II) complexes with L1 ligand synthesized from copper chloride and copper acetate with addition of sodium azide have been determined by X-ray diffraction. The azomethines and all copper(II) complexes have been screened for their antibacterial, protistocidal, and fungistatic activities against Penicillium italicum, Colpoda steinii, Escherichia coli 078, and Staphylococcus aureus P-209. © 2021 Elsevier B.V.

Vlasenko V.G. 1 , Burlov A.S. 2 , Koshchienko Y.V.2 , Kolodina A.A.2 , Chaltsev B.V.2 , Zubavichus Y.V. 3 , Khrustalev V.N. 4, 5 , Danilenko T.N.6 , Zubenko A.A.7 , Fetisov L.N.7 , Klimenko A.I.7
  • 1 Southern Federal University, Institute of Physics, Stachki ave. 194, Rostov-on-Don, 344090, Russian Federation
  • 2 Southern Federal University, Institute of Physical and Organic Chemistry, Stachki ave. 194/2, Rostov-on-Don, 344090, Russian Federation
  • 3 Boreskov Institute of Catalysis SB RAS, Lavrentiev Ave. 5, Novosibirsk, 630090, Russian Federation
  • 4 People's Friendship University of Russia (RUDN University), Miklukho-Maklaya ul. 6, Moscow, 117198, Russian Federation
  • 5 N. D. Zelinsky Institute of Organic Chemistry RAS, Leninsky Prosp. 47, Moscow, 119991, Russian Federation
  • 6 Don State Technical University, pl. Gagarina 1, Rostov-on-Don, 344010, Russian Federation
  • 7 North-Caucasian Zonal Scientific Research Veterinary Institute – Branch of the Federal State Budget Scientific Institution “Federal Rostov Agricultural Research Centre”, Rostov highway, 0, Novocherkassk, 346421, Russian Federation
Ключевые слова
Azomethines; Biological activity; Copper(II) complex; X-ray absorption spectroscopy; X-ray diffraction
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