Effect of Nasal Obstructive Disorders on Sinonasal Symptoms in Children with Different Levels of Bronchial Asthma Control

Allergic rhinitis (AR) and allergic rhinosinusitis (ARS) are typical upper airway pathologies (UAP) in children with bronchial asthma (BA) frequently accompanied with nasal obstructive diseases (NOD). In order to establish the effect of NOD on correlations between nasal and synonasal symptoms with clinical assessments of asthma control, 82 children, 9.8 [8.9; 10.7] years old, with atopic BA were assessed using ACQ-5 for the BA control level, TNSS for nasal symptoms, and SNOT-20 for synonasal quality of life in combination with rhinovideoendoscopy for NOD. All patients had AR/ARS; in 76.3% (63/82) of children, UAP had a multimorbid character with the presence of NOD. Significant correlations were found between ACQ-5 and TNSS (R=0.40, p<0.0001) and ACQ-5 and SNOT-20 (R=0.42, p<0.0001). Correlations between TNSS/ACQ-5 and SNOT-20/ACQ-5 were higher in patients who do not have a combination of AR/ARS with NOD (R=0.67, p=0.0012; R=0.50, p=0.022, resp.) than in patients who have AR/ARS combined with NOD (R=0.30, p=0.015; R=0.26, p=0.04, resp.). Thus, the association of BA control level with the expression of nasal and synonasal symptoms is higher in children who do not have multimorbid UAP. © 2018 T. I. Eliseeva et al.

Eliseeva T.I.1 , Krasilnikova S.V.1 , Geppe N.A.2 , Babaev S.Y.1 , Tush E.V.1 , Khaletskaya O.V.1 , Ovsyannikov D.Y. 3 , Balabolkin I.I.4 , Ignatov S.K.5 , Kubysheva N.I.6
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  • 1 Department of Hospital Pediatrics and Department of ENT Diseases, Nizhny Novgorod State Medical Academy, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russian Federation
  • 2 Department of Children Diseases, I.M. Sechenov First Moscow State Medical University, 8 Bld. 2 Trubetskaya St., Moscow, 119991, Russian Federation
  • 3 Department of Pediatrics, Medical Institute, Peoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St., Moscow, 117198, Russian Federation
  • 4 Russian Academy of Sciences, Department of Pulmonology and Allergology, National Scientific and Practical Centre of Children's Health, Lomonosovsky Avenue, Moscow, 119991, Russian Federation
  • 5 Department of Chemistry, Lobachevsky State University of Nizhny Novgorod, 23 Gagarin Avenue, Nizhny Novgorod, 603950, Russian Federation
  • 6 Med. Info. Res. Laboratory of the Higher School of Information Technologies and Information Systems, Kazan Federal University, 18 Kremlyovskaya St., Kazan, Republic of Tatarstan, 420008, Russian Federation
Ключевые слова
adolescent; allergic asthma; allergic rhinitis; Article; asthma; Asthma Control Questionnaire; child; childhood disease; disease severity; female; forced expiratory volume; forced vital capacity; human; laryngoscopy; major clinical study; male; nose obstruction; priority journal; quality of life; rhinosinusitis; scoring system; Sino Nasal Outcome Test; spirography; Total Nasal Symptom Score; videoendoscopy
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