Therapy-related acute myeloid leukemia and its prevention

Background: Secondary tumors, including therapy-related acute myeloid leukemia (t-AML), represent one of the most undesirable side effects of chemotherapy, which arise several years after primary cancer treatment. This review aims to analyze the current data on molecular pathogenesis of t-AML revealing potential criteria for predicting predisposition to the disease. Another objective is to analyze the information on promising approaches for t-AML prevention. Methods: We analyzed studies regarding t-AML and possible approaches for cancer prevention of drug-induced tumors. Publications in the databases, such as SciVerse Scopus (948), PubMed (1837) and Web of Science (935) were used. Among 92 the most important publications cited in the review, 79 were published during the last decade. Results: The review provides the information concerning t-AML pathogenesis, molecular markers of primary cancer patients with high risk of t-AML. The role of the bone marrow niche in clonal hematopoiesis and t-AML pathogenesis is discussed. Current approaches for t-AML prevention both at the stage of therapy and at the latent period are described. Inhibition effects of polyphenols on cell proliferation and on the appearance of hemopoetic clones of indeterminate potential are proposed for t-AML prevention. Conclusion: The problem of the t-AML, a cancer induced by genotoxic chemotherapeutic drugs, is considered from the point of view of the fundamental mechanisms of chemical carcinogenesis, highlighting initiation and promotion stages. It enables to reveal the possible markers for the group of patients with high risk for t- AML and to demonstrate perspectives for the use of plant polyphenols for t-AML prevention.

Авторы
Belitsky G. 1 , Fetisov T.1 , Kirsanov K. 1, 2 , Lesovaya E.1, 3 , Vlasova O.1 , Yakubovskaya M.1
Издательство
E-CENTURY PUBLISHING CORP
Номер выпуска
6
Язык
Английский
Страницы
416-433
Статус
Опубликовано
Том
10
Год
2020
Организации
  • 1 Minist Hlth Russian Federat, Blokhin Natl Med Res Ctr Oncol, Dept Chem Carcinogenesis, Moscow 115478, Russia
  • 2 Peoples Friendship Univ Russia, Fac Basic Therapy, Moscow 117198, Russia
  • 3 Pavlov Ryazan State Med Univ, Div Oncol, Ryazan 390026, Russia
Ключевые слова
Therapy-related cancer; leukemia; stem cells; metastatic niches; cytotoxic drugs; prevention of secondary AML; plant polyphenols
Дата создания
19.05.2021
Дата изменения
19.05.2021
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/73528/
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