Redox-Dependent Expression of Genes Encoding NADPH Oxidase 5 and the Key Antioxidant Enzymes during Formation of Drug Resistance of Tumor Cells to Cisplatin

Expression of genes that plays a significant role in the control of cellular redox homeostasis was studied during the development of drug resistance of human ovarian adenocarcinoma SKOV-3 cells to cisplatin. It was found that the development of drug resistance was accompanied by enhanced expression of the genes encoding the key antioxidant enzymes (SOD2, CAT, GPX1, and HO-1) and transcription factor Nrf2, as well as reduced expression of the gene encoding NOX5 isoform of NADPH oxidase. The results testify to redox-dependent development of the adaptive antioxidant response as an important process in the mechanism of formation of resistance to cisplatin. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.

Kalinina E.V. 1 , Andreev Y.A. 2 , Petrova A.S. 1 , Lubova K.I.2 , Shtil’ A.A.3 , Chernov N.N. 1 , Novichkova M.D. 1 , Nurmuradov N.K. 1
New York Consultants BureauSpringer / Автономная некоммерческая организация Издательство Российской академии медицинских наук
  • 1 Peoples’ Friendship University of Russia, Moscow, Russian Federation
  • 2 M. M. Shemyakin and Yu. A. Ovchinnikov of Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russian Federation
  • 3 N. N. Blokhin National Medical Research Center of Oncology, Ministry of Health of the Russian Federation, Moscow, Russian Federation
Ключевые слова
antioxidant enzymes; cisplatin; drug resistance of tumor cells; gene expression; NADPH oxidase 5
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