Synthesis and cytotoxicity of dibenzo[(γ-aryl)pyridino]aza-17-crown-5 ethers

For the development of new anticancer agents, dibenzo[(γ-aryl)pyridino]aza-17-crown-5 ethers containing 2,4,6-triarylpyridine were synthesized successfully by one-step domino-condensation of 1,8-bis(2-acetylphenoxy)-3,6-dioxaoctane, arylaldehydes and ammonium acetate according to the conditions of Hantzsch reactions. The synthesized γ-arylpyridine derivatives show high cytotoxic activity against human cancer cell lines: Hep-G2, RD, FL, Lu1. Compounds (3b,c) showed significant cytotoxicity against all four human cell lines whereas the similar synthesized compound (3d) possessed cytotoxicity against HepG2, Lu1 and RD cell lines. Meantime, both compounds (3f,g) containing γ-heteroaryl only exhibited cytotoxicity against RD and FL cell lines. Azacrown ethers (3b-d) exhibited low activity on the Vero cell line, meaning that they can be evaluated for their potential as promising anticancer agents. X-Ray structure study was performed to determine the structure of the representative compound 3a. © ISUCT Publishing.

Авторы
Anh L.T. 1 , Phuong N.T.T.1 , Hieu T.H. 2 , Soldatenkov A.T. 3 , Van B.T.1 , Van T.T.T.1 , Nhung D.T.1 , Voskressensky L.G. 3 , Tung T.H.1 , Khrustalev V.N. 3, 4
Редакторы
-
Журнал
Издательство
-
Номер выпуска
2
Язык
Английский
Страницы
197-202
Статус
Опубликовано
Подразделение
-
Номер
-
Том
11
Год
2018
Организации
  • 1 Department of Pharmaceutical Chemistry, Faculty of Chemistry, VNU University of Science, Hanoi, 100000, Viet Nam
  • 2 Department of Biotechnology, Vietnam-Russia Tropical Centre, Hanoi, 100000, Viet Nam
  • 3 Faculty of Science, Peoples’ Friendship University of Russia, Moscow, 117198, Russian Federation
  • 4 X-Ray Structural Centre, A.N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, Moscow, 119991, Russian Federation
Ключевые слова
Anticancer agent; Arylpyridine; Azacrown ethers; Cytotoxicity; Hantzsch reaction; X-ray analysis
Дата создания
19.10.2018
Дата изменения
19.10.2018
Постоянная ссылка
https://repository.rudn.ru/ru/records/article/record/7332/